Read More fluvoxamine The Fluvoxamine FAQ Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. It is very important to educate doctors because most people rely on their doctors for advice. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. Some countries dont have fluvoxamine so this is the alternative. Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. The drug was FDA-approved more than 65 years ago. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Drug researchers at Washington University in St. Louis reached out to Kirsch looking for $67,000 to finish a very smallbut placebo-controlledtrial. Fluvoxamine has at least a 30% hospitalization and death benefit. Dosage there is 30mg once a day. This site requires JavaScript to run correctly. Doctors have no excuse for not prescribing. I will . Medicine today isnt about saving your life. Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008 Google Docs This is a more comprehensive look at the key evidence supporting fluvoxamine: Fluvoxamine for COVID-19 But thats not a surprise, according to researchers who conducted them: the vast majority of trials for any drug end in failure. Or just depression about the vaccine mandates? . . So take the lowest likely effect size * 60% success rate and you are looking at an expected 45% reduction in death which is clearly better than a 0% reduction. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. Steve Kirsch is baffled. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. Its whether Merck can make a killing that matters. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. Some countries dont have fluvoxamine so this is the alternative. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. Ive used it personally at 50mg twice a day and experience no adverse events at all. Steve Kirsch is looking for an explanation for 171,000 excess deaths. Always be self aware when using fluvoxamine. Zero. Everyone is stunned, but nobody is surprised. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. Completely avoid caffeine, alcohol, tylenol, and benadryl. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. 95% confidence effect size is 75% or more. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? So you can address your OCD and if you get COVID, youll can up the dose. I was just getting tired, he said, before asking to speak off the record. You can use fluoxetine as well (aka Prozac). A very short op-ed arguing for using fluvoxamine against COVID. Jeffrey Glenn, an infectious disease professor at Stanford University, calls the inaction on the current evidence on the table "criminal.". Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. He has been a medical philanthropist for more than 20 years. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. They knew in advance it was coming and on the day the paper was published they ignored it entirely. Can I see your risk-benefit analysis?. . Im sorry to sound so cynical. Substitutions. So far, doctors have failed to share his sense of urgency. Their willingness to lie did. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. I have all of these on hand and I load up on vitamin D3 every day. . Were having trouble saving your preferences. May 16, 2022. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. The rest of the board soon followed. About 10 minutes on the internet will show you those two gentlemen, who have appeared together, have been extensively fact checked for false or misleading claims or misuse of VAERS reporting and other data. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Early treatment with existing drugs is the fastest, most effective, and lowest. It could do nothing. Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. Hes a genuinely good guy. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. 4000fluvoxamine750 But the potential upsides. Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. In short, a lot of mumbo jumbo. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. An approach that promised to democratize design may have done the opposite. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. Twenty-four years ago, . It will be months before enrollments are complete. Im just telling you the truth. . Links to evidence about fluvoxamine including the public data repository. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. The anecdotal data of 100% success rates is further icing on the cake. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. I believe they made the right decision and we should be rushing to follow their advice. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. Waiting months for the phase 3 trial to complete is nuts. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. He's founded 7 companies, 2 with billion dollar valuations. See more below. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Don't underestimate the virus. No long haul symptoms if you start the drug ASAP after first symptoms. I've collected fluvoxamine evidence here for convenient access. Stopping the meds will return you to your normal self. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. In September, he resigned as CEO and gave up his board seat. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. An MIT Technology Review investigation recently revealed how images of a minor and a tester on the toilet ended up on social media. 1:49 Steve put in $1MM of his own money and . I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? But how many did it help? The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. All the medical journals refused to publish the meeting notes (rejected by 6 journals). The medical community doesnt care about saving lives. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here.. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. So much for evidence-based medicine. Fluoxetine is just as effective. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. Part of TV News Archive. See my article on treatments. Eventually, a press representative who was listening in, David Satterfield, unmuted his microphone to suggest we finish our conversation by email. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. JAMA systematic review and meta analysis It doesnt get any better than this. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. All the researchers are convinced the drug works. Items included in the Television News search service. Ive used it personally at 50mg twice a day and experience no adverse events at all. There may be a depression of libido while on drug, but since the drug is taken on acute basis, this is only temporary and it reverses once the drug is stopped. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. We look for advances that will have a big impact on our lives and break down why they matter. But fear of trying something new prevents any doctor from giving this drug a try. While combining the results of several well-designed trials can strengthen an argument or unearth patterns unseen in smaller samples, a meta-analysis is just the sum of its parts; any single well-done experiment is more useful than combining the results of several poorly done ones. The data is there in plain sight for anyone to see today. The sooner you start, the better the outcomes. YouTube , , , fluvoxamine, , , , , , , , , , Physicians who use the drug for COVID now swear by it. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. All can merit a fluvoxamine prescription based on traditional diagnoses. I think we did rigorous reviews of proposals for research.. A video presentation by Steve Kirsch, Executive Director of the Covid-19 Early Treatment Fund. Compulsive hand washing? @stkirsch. The evidence is solid. All the supporting observational studies were positive as well. The NIH wrote a bullshit rejection because the FDA told them not to approve it. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Comparison with molnupiravir. The next major effect is that that fluvoxamine activates the sigma-1 receptor. Fluoxetine is just as effective. Or just depression about the vaccine mandates? There were IRB rules that required the 65 patients to be listed in the diagrams and charts. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. If you cant lay off the java, then try fluoxetine (Prozac). skirsch.io Steve Kirsch Home page. He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. If you take fluvoxamine, please avoid caffeine while on the drug. We didnt come up with better mouse technology than Microsoft did. The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). Always be self aware when using fluvoxamine. Now they turn to Rust. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. The combined p value of the two studies is <.0001. just like ivermectin). Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. (article I did after the TOGETHER trial). In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. The findings, published Wednesday in the New England Journal of Medicine, add to a growing body of scientific evidence pushing back against the use of the antiparasitic drug that has been promoted by some prominent voices on social media. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. Timing is everything with respect to outcomes. Consider masks by contrast. Thanks for working tirelessly to help others. Hes now outlived his initial prognosis by several years. 90,000 people don't have to die in the next 3 weeks. . That way you can start immediately. He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. No long haul symptoms if you start the drug ASAP after first symptoms. . Where did it go wrong. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). Get your prescription in advance of getting COVID. Los Altos Hills resident Steve Kirsch funded research into the drug fluvoxamine as a treatment for COVID-19. Do they sell it anywhere? There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Last Checked: 03/03/2023. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. P-value was 10^-14 on that study (done by Dr. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug.
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