View. Mayo Clinic is a not-for-profit organization. It is normal for many of these cells to die off in the process. But sun exposure doesn't explain skin cancers that develop on skin not ordinarily exposed to sunlight. If you have an uneven skin texture, you can't help but notice how bumpy your skin feels. Its not often used as the first treatment for younger patients because of the possible risk of long-term problems. See pictures and learn about causes, prevention, diagnosis, treatment, and, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. The atypical skin lesions are a diverse group of tumors that are uncommon but clinically important. 11th ed. receive emails from Mayo Clinic on the latest about cancer news, research, and care. Because BCC is at work in most keratinocyte cancer cases, this article focuses primarily on the causes of BCC, as well as symptoms that suggest it may be time to call your healthcare provider. When atrophy only affects certain areas of the prostate, it is called focal atrophy. According to the American Academy of Dermatology, cSCC is most commonly red or pink. Squamous cell carcinoma of the skin. Most cases of cSCC are attributed to exposure to UV radiation from sunlight or indoor tanning equipment like tanning lamps and beds. Different types of surgery can be used to treat squamous cell skin cancers. Histologically, Bowen disease presents as intraepithelial atypia, with marked variation in cell and nuclear size . cSCC often develops in areas of the body that are frequently exposed to UV radiation, such as your face, hands, and ears. Include any more information that will help us locate the issue and fix it faster for you. Bookshelf BMC Cancer. An atypical mole is not a skin cancer but having these moles is a risk factor for developing melanoma. Careers. Although this seems like a prudent approach, scientific evidence for this is . What are basal and squamous cell skin cancers? The https:// ensures that you are connecting to the Is squamous cell carcinoma a serious disease? 2005-2023 Healthline Media a Red Ventures Company. 4 The . Nonmelanoma skin cancers: Basal cell and squamous cell carcinomas. Keep reading to learn more about this type of skin cancer, what it looks like, what causes it, and how its diagnosed and treated. According to the American Cancer Society, basal cell carcinoma makes up about 80 percent of skin cancers. Or it can be the result of a specific treatment. Can a Pap smear detect atypical squamous cells? A biopsy usually involves removing a very small portion of the affected skin. Chemotherapy and sex: Is sexual activity OK during treatment? Check with your dermatologist if a skin growth dramatically increases in size or changes its shape. Your in-depth coping with cancer guide will be in your inbox shortly. All of the tumors showed a distinct exophytic papillary configuration with prominent fibrovascular cores lined by an atypical squamous proliferation composed of smaller cells at the base with indistinct cell membranes . The majority of SCC patients have a good prognosis. It often forms on parts of your skin frequently exposed to sunlight like your face, neck, or arms. Member. An atypical mole, also sometimes called a dysplastic nevus, is a benign but unusual-looking mole that can look a lot like a melanoma . Check all that apply - Please note that only the first page is available if you have not selected a reading option after clicking "Read Article". }. This site needs JavaScript to work properly. Depending on the type, skin cancer can grow rapidly and become life-threatening. Examine both the front and back of your legs and your feet, including the soles and the spaces between your toes. Mayo Clinic does not endorse companies or products. However, as we'll expand on below, their presence is an indicator of an increased melanoma risk in general. Atypical moles carry some of the same mutations found in melanomas, but significantly fewer. Atypical Squamous Cells (ASC) refers to an unclear result from a pap smear that requires a repeat pap smear. Atypical cells don't necessarily mean you have cancer. Guidelines of care for the management of cutaneous squamous cell carcinoma. Look for those that block both types of UV radiation UVA and UVB rays. Niederhuber JE, et al., eds. Typical SCC has nests of squamous epithelial cells arising from the epidermis and extending into the dermis (figure 1). Treating Basal and Squamous Cell Skin Cancer, About Basal and Squamous Cell Skin Cancer, Making Strides Against Breast Cancer Walks, ACS Center for Diversity in Research Training, Surgery for Basal and Squamous Cell Skin Cancers, Local Treatments Other than Surgery for Basal and Squamous Cell Skin Cancers, Radiation Therapy for Basal and Squamous Cell Skin Cancers, Systemic Chemotherapy for Basal and Squamous Cell Skin Cancers, Targeted Therapy for Basal and Squamous Cell Skin Cancers, Immunotherapy for Advanced Basal or Squamous Cell Skin Cancers, Treating Squamous Cell Carcinoma of the Skin, Treating Actinic Keratosis and Bowen Disease. A mutation in the DNA may cause a basal cell to multiply fast and continue growing when it would normally die. Mayo Clinic, Rochester, Minn. June 4, 2019. Howell JY, et al. 2019. Squamous cell carcinoma of the skin is a common form of skin cancer that develops in the squamous cells that make up the middle and outer layers of the skin. The reason for its lack of being in the skin cancer conversation is that atypical fibroxanthoma is quite rare, accounting for less than 0.2% of all skin . Accessed May 14, 2019. AKs are defined at the histologic level by dysplasia and consist of keratinocytes manifesting atypical nuclei that are enlarged, irregular, and hyperchromatic. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. You can change your cookie settings through your browser. Wear sunscreen that has an SPF of at least 30 whenever you go out in the sun. However, these drugs havent been studied in people with weakened immune systems, such as people who take medicines for autoimmune diseases or who have had an organ transplant, so the balance between benefits and risks for these people isnt clear. Alam M, et al. In 1992, the NIH recommended that the term "dysplastic nevus" be avoided in favor of the term "atypical mole". These lesions, once diagnosed as atypical, are typically excised to eliminate the risk of cancer. A cell's DNA contains the instructions that tell a cell what to do. Although cSCC isnt life threatening, it can become dangerous if it goes untreated. The five visual characteristics used to identify an atypical melanocytic lesion are the same as the characteristics used to identify signs of invasive melanoma. Christensen SR, Wilson LD, Leffell DJ. Do not surround your terms in double-quotes ("") in this field. Understanding cervical changes: Next steps after an abnormal screening test. Squamous cells can be found in a variety of locations throughout the body. Skin cancer types: basal cell carcinoma signs and symptoms. include protected health information. Here you'll find in-depth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options. Click here for an email preview. Atypical Melanocytic lesions are irregular moles and skin spots that require further examination. Squamous cell carcinoma of the skin is usually not life . They occasionally present as dark skin focalities, especially when found in the genital region and the nails. Skin squamous cell carcinoma is usually non-life-threatening, but it can be aggressive. enable-background: new; Posts: 5. A clinicopathologic and immunohistochemical study of 30 cases, with emphasis on "atypical fibroxanthomas". Radiation is sometimes used after surgery (simple excision or lymph node dissection) if all of the cancer was not removed (if the surgical margins were positive), if nerves are involved, or if there is a chance that some cancer may still be left. The increased proliferative activity of endothelial cells in CIN IIIII lesions suggests that they are angiogenically more active than condylomas and CIN I lesions, which does not, however, depend on the HPV or p53 status. Treatment is based on: If cSCC is caught early, the condition can usually be successfully treated. But it can occur anywhere on your body, including inside your mouth, the bottoms of your feet and on your genitals. Squamous cells are found in many places in your body, and squamous cell carcinoma can occur anywhere squamous cells are found. What are the causes and risk factors for squamous cell cancer? sharing sensitive information, make sure youre on a federal Sign up today, get DeepDyve free for 14 days. They include a spectrum from benign lesions through to those that demonstrate local invasion and/or distant metastatic potential. When treatment isnt received quickly, the growths can increase in size and spread to other parts of your body, causing serious complications. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019. Advertising revenue supports our not-for-profit mission. Examine your chest and trunk and the tops and undersides of your arms and hands. With the help of mirrors, check your face, neck, ears and scalp. In: Clinical Dermatology: A Color Guide to Diagnosis and Therapy. BCC occurs when one of the basal cells of the epidermis develops a mutation, or change, in its DNA. Verrucous carcinoma is a rare, well-differentiated variant of squamous cell carcinoma that commonly arises on the feet. .st3 { Eruptive squamous atypia (ESA), which is an idiopathic, sometimes koebnerizing, proliferation of atypical but well-differentiated keratinocytes (also termed eruptive keratoacanthoma), is often misdiagnosed as cancer and managed by excisional surgery, provoking further koebnerization. Multiple self-healing squamous epithelioma (MSSE), also known as Ferguson-Smith disease, is a rare inherited cancer that can heal itself on its own. The histopathologic changes noted in keratinocytic proliferative lesions involve disturbance of normal surface maturation. Lymph node dissection: Removing regional (nearby) lymph nodes might be recommended for some squamous cell cancers that are very large or have grown deeply into the skin, as well as if the lymph nodes feel enlarged and/or hard. What are the other Names for this Condition? This site complies with the HONcode standard for trustworthy health information: verify here. a topic. Squamous cell carcinoma of the skin refers to cancer that forms in the squamous cells found in the skin. Many treatments can be performed as in-office procedures. They usually form on the head, face, neck, hands, and arms. Whether you want to learn about treatment options, get advice on coping with side effects, or have questions about health insurance, were here to help. What are the top 10 largest cities in Wisconsin? Squamous cell carcinomas usually look like an abnormal wart, rash or wound on the skin that does not heal. You can learn more about how we ensure our content is accurate and current by reading our. To help reduce your risk of cSCC, follow these tips when possible: Early detection of cSCC is key to successful treatment. One type of skin cancer called basal cell carcinoma begins in the basal cells, which make skin cells that continuously push older cells toward the surface. This can happen spontaneously. Check your skin each month for any new or abnormal growths. Make a donation. Skip to Article Content; Skip to Article Information . The cutaneous horn appears as a funnel-shaped growth that extends from a red base on the skin. Signet ring cell squamous cell carcinoma. Skin cancer is an early-forming skin cancer that is limited to the upper layers of the skin and is known as in-situ. Squamous cell carcinomas can appear in the skin as flat reddish or brownish patches with a rough, scaly, or crusted surface. A clear definition of this phenomenon and treatment outcome data are lacking. These are called the ABCDE's of melanoma. Untreated squamous cell carcinoma of the skin can destroy nearby healthy tissue, spread to the lymph nodes or other organs, and may be fatal, although this is uncommon. other information we have about you. 6th ed. Squamous cells, which resemble fish scales, are thin, flat cells found in the tissue that makes up the skins surface, the lining of the bodys hollow organs, and the lining of the respiratory and digestive tracts. The malignant cells are often large with abundant eosinophilic cytoplasm and a large, often vesicular, nucleus. The changes are almost always indicative of an HPV infection. Casey Gallagher, MD, is board-certified in dermatology and works as a practicing dermatologist and clinical professor. A new sore or raised area on an old scar or ulcer, A rough, scaly patch on your lip that may evolve to an open sore, A red sore or rough patch inside your mouth, A red, raised patch or wartlike sore on or in the anus or on your genitals, Involves the mucous membranes, such as the lips, Occurs in a person with a weakened immune system, such as someone who takes anti-rejection medications after an organ transplant or someone who has chronic leukemia. Their findings could be beneficial to many other more common types of cancer, as well as solving a long-standing mystery. (2021). The first two skin cancers are grouped together as non-melanoma skin cancers . The epidermis has three main types of cells: The cells of the epidermis are constantly shedding to make way for fresh, new skin cells. Unauthorized use of these marks is strictly prohibited. Habif TP. Journal of the American Academy of Dermatology. For squamous cell carcinomas, Mohs surgery has the highest cure rate of all treatments. Specifically, this cancer can appear as: A round, firm growth that may crust or bleed An open sore that may crust or bleed A red, scaly patch that may crust or bleed An elevated growth with a depression that may crust, bleed or expand rapidly That is why it is important to be aware of these moles, get them checked by your dermatologist, and watch out for changing moles. Curettage and electrodesiccation: This approach is sometimes useful in treating small (less than 1 cm across), thin squamous cell cancers, but its not recommended for larger tumors. The American Cancer Society medical and editorial content team. journals.lww.com/dermatologicsurgery/Fulltext/2015/04000/Family_History_of_Skin_Cancer_Is_Associated_With.7.aspx, cancer.org/cancer/basal-and-squamous-cell-skin-cancer/causes-risks-prevention/risk-factors.html, cancer.gov/about-cancer/treatment/drugs/skin, cancer.gov/types/skin/hp/skin-genetics-pdq, cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq, skincancer.org/skin-cancer-information/skin-cancer-facts/, aad.org/public/diseases/skin-cancer/types/common/scc/symptoms, aad.org/public/diseases/skin-cancer/types/common, mskcc.org/cancer-care/types/mouth/types-mouth, cancer.org/cancer/basal-and-squamous-cell-skin-cancer/about/what-is-basal-and-squamous-cell.html, Prognosis and Outlook for Stage 4 Squamous Cell Carcinoma, Carcinoma Types: Squamous Cell, Basal Cell, Transitional Cell, and More, Survival Rates for Different Types of Skin Cancer, What You Need to Know About Skin Cancer on the Scalp, Everything You Need to Know About Nonmelanoma Skin Cancer, Mohs Surgery for Basal Cell Carcinoma: Before and After Treatment. Cover your skin with dark, tightly woven clothing that covers your arms and legs, and a broad-brimmed hat, which provides more protection than does a baseball cap or visor. An atypical mole may also be referred to as an atypical melanocytic . Joined: Nov 2009. . Problems in the current TNM staging of nonmelanoma skin cancer of the head and neck. A dysplastic nevus or atypical mole is a nevus (mole) whose appearance is different from that of common moles. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. 2019;25(8):2379-2391. doi: 10.1158/1078-0432.CCR-18-1122. Keratinocyte carcinomas: current concepts and future research priorities. Variable keratinisation ( keratin pearls etc) is present (figure 2). Atrophy is a term used to describe a shrinkage of prostate tissue (when it is seen under the microscope). Accessed May 14, 2019. Learn how to tell if you have it and how you can reduce your risk. Squamous cell carcinoma of the skin care at Mayo Clinic. It has a lower malignancy potential than conventional squamous cell carcinomas. Atypical cells don't necessarily mean you have cancer. What exactly are atypical squamous cells in this regard? Basal cell carcinoma is the far more common of this skin cancer type. Anyone can get skin cancer, but it is more common in people who : other information we have about you. Research. Also check your genital area and between your buttocks. BCCs usually develop on sun-exposed parts of your body, especially your head and neck. SCC is characterised by proliferation of irregular nests of abnormal squamous cells arising from the epidermis and invading the dermis. the unsubscribe link in the e-mail. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. We're improving the lives of cancer patients and their families through advocacy, research, and patient support to ensure that everyone has an opportunity to prevent, detect, treat, and survive cancer. Skin cancer has a high cure rate, but only if caught early. Theyll also ask you about your medical history. First lady Jill Biden is undergoing Mohs surgery to remove a skin lesion above her eye. Squamous cell carcinoma and basal cell carcinoma are also called nonmelanoma skin cancers. We couldnt do what we do without our volunteers and donors. What does this mean? National Cancer Institute. To save an article, log in first, or sign up for a DeepDyve account if you dont already have one. In people with darker skin, this type of cancer may look brown or black. A Study Says UV Nail Dryers May Pose Skin Cancer Risks. Review/update the Treatment and prognosis of low-risk cutaneous squamous cell carcinoma. OP. Sometimes the skin around the tumor gets red and swollen. However, having less pigment (melanin) in your skin provides less protection from damaging UV radiation. Make an appointment with your healthcare provider if you have any signs or symptoms that worry you. information highlighted below and resubmit the form. Its most common on skin areas that have been exposed to strong sunlight on a regular basis, such as the head, ears, and hands. High-risk tumors, on the other hand, have a less favorable prognosis, with a risk of metastasis of up to 48%. Learn. They were placed on your computer when you launched this website. Diagnosis confirmation When cancer develops in melanocytes, the condition is known as malignant melanoma. Sun safety. What are the symptoms of squamous cell cancer? Atypical Squamous Proliferation: What Lies Beneath?, Dermatologic Surgery | 10.1111/j.1524-4725.2011.01895.x | DeepDyve Enterprise Plans Free Trial Browse Features Pricing DeepDyve Get 20M+ Full-Text Papers For Less Than $1.50/day. In the past few years there has been an increase in the . To protect yourself: Wear protective clothing. And sometimes, your doctor may need to obtain a sample of tissue such as a biopsy to make sure you don't have cancer or another serious condition. Squamous cell carcinoma - typical features. Protect your skin during winter as well because winter UV rays can be especially dangerous. Mohs surgery might also be done after an excision if it didnt remove all of the cancer (if the surgical margins were positive). The majority of SCCs begin as AKs. In-situ means the skin cancer it is an early forming skin cancer and is limited to the upper layers of the skin. Most BCCs are linked to long-term exposure to and damage from ultraviolet (UV) radiation. If you are a Mayo Clinic patient, this could Available Every Minute of Every Day. Journal of the American Academy of Dermatology. Patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin a casecontrol study. Start a 14-Day Trial for You or Your Team. This can happen spontaneously. If you have blond or red hair and light-colored eyes and you freckle or sunburn easily, you're much more likely to develop skin cancer, including squamous cell carcinoma, than is a person with darker skin. KASP: keratoacanthomatous atypical squamous proliferation SCC: squamous cell carcinoma STSG: split-thickness skin graft From the Department of Dermatology, Feinberg School of Med-icine, Northwestern University. Subscribe for free and receive an in-depth guide to coping cSCC is caused by mutations that occur in squamous cell DNA. You may opt-out of email communications at any time by clicking on However, it can also appear in your mouth, around your anus, and on your genitals. Mouth sores caused by cancer treatment: How to cope, No appetite? Member. Skin cancer is the most common form of cancer in the United States. As a stand-along diagnosis, I would code "atypical melanocytic proliferation" or "melanocytic proliferation" D48.5 (neoplasm of uncertain behavior). (A biopsy means that tissue was removed from the body for examination in a laboratory.) Its also important to follow recommended screening guidelines, which can help detect certain cancers early. SEBASTIAN, SHELDON; YANKO, RAVIT; GOLDSTEIN, GLENN D. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/wolters-kluwer-health/atypical-squamous-proliferation-what-lies-beneath-YyR97Kh0xd. The risk of aggressive squamous cell carcinoma of the skin may be increased in cases where the cancer: Most squamous cell carcinomas of the skin can be prevented. When your skin starts producing more collagen, it will naturally plump your skin and create a more even texture. Copyright 2023 Elsevier Inc. All rights reserved. Tumours are traditionally divided into well, moderately or poorly differentiated tumours by a subjective assessment of how significantly the tumour cells differ from normal keratinocytes. Most of the DNA mutations in skin cells are caused by ultraviolet (UV) radiation found in sunlight and in commercial tanning lamps and tanning beds. The lesions may ulcerate and cause scarring of skin The treatment of choice is a surgical excision with clear margins followed by radiation therapy or chemotherapy, as decided by the healthcare provider. Once advanced squamous cell carcinoma has spread to the lymph nodes and beyond, the survival rates are lower. Become a volunteer, make a tax-deductible donation, or participate in a fundraising event to help us save lives. When a squamous cell carcinoma is diagnosed, most people are only familiar with the term. AskMayoExpert. Squamous cell cancer (SCC), also known as squamous cell carcinoma, is a type of cancer. 2018;78:560. Facial Plast Surg Clin North Am. Other potential causes include: Treatment for cSCC varies. Cryosurgery. https://www.cancer.gov/types/cervical/understanding-cervical-changes. 1 First-line treatment is complete surgical excision or Mohs micrographic surgery (MMS), 2 although amputation is often performed due to local tissue destruction and late intervention. In other cases, your doctor may recommend a particular treatment to try to reverse the process that's causing the atypical cells. Cells become damaged for many reasons, and the progression of that damage from normal to malignant is a cascade . To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you dont already have one. Mayo Clinic does not endorse any of the third party products and services advertised. All rights reserved. Incomplete primary excision of cutaneous basal and squamous cell carcinomas in the Bay of Plenty. It's important to be aware of these moles, because they can turn into melanomas. Squamous cells can be found in the mouth, lips, and cervix. Here's how to tell them apart. Many factors can make normal cells appear atypical, including inflammation and infection. The main types of skin cancer are: Squamous cells are the cells closest to your skins surface, and their purpose is to line your skin. Article. Squamous cell carcinoma on the skin can grow big or spread to other parts of your body if left untreated, resulting in serious complications. This content does not have an Arabic version. sheldon.sebastian@gmail.com; PMID: 21342317 DOI: 10.1111/j.1524-4725.2011.01895.x No abstract available. What are the six major characteristics of a pure market economy. We can also help you find other free or low-cost resources available. Accessed at https://www.uptodate.com/contents/treatment-and-prognosis-of-low-risk-cutaneous-squamous-cell-carcinoma on June 4, 2019. Journal of the American Academy of Dermatology. They grow slowly and are usually found on sun-exposed parts of the body, such as the face, ears, neck, lips, and hands backs. Atypical cells can change back to normal cells if the underlying cause is removed or resolved. This suggests that other factors may contribute to your risk of skin cancer. 2018 May;80(2):303-317. doi:10.1016/j.jaad.2018.03.060, Iannacone MR, Wang W, Stockwell HG, et al. Squamous cell carcinoma can spread to the sinuses, skull base, and other parts of the brain. This is based on a consult with a dermamtopathologist. Both are of the keratinocyte type. } . To provide you with the most relevant and helpful information, and understand which How to get nutrition during cancer treatment, Infographic: Scalp Cooling Therapy for Cancer, Stem cells: What they are and what they do, Thalidomide: Research advances in cancer and other conditions, TVEC (Talimogene laherparepvec) injection, When cancer returns: How to cope with cancer recurrence, Advertising and sponsorship opportunities. Jill Biden and Skin Cancer: What to Know About Risks, Screenings, and Surgery, Basal Cell Carcinoma of the Nose: Types, Identification, and Treatment, keratinocytes (skin cells, also called squamous cells), an open sore that can have raised borders, new growth on an old scar, birthmark, or mole, having light-colored hair and blue, green, or gray eyes, having long-term exposure to UV radiation, living in sunny regions or at a high altitude, having a history of multiple severe sunburns, especially if they occurred early in life, having a history of being exposed to chemicals, such as arsenic. Stage 1 Cancer has spread deep into the skin but has not spread to nearby lymph nodes or healthy tissues. Thank you, {{form.email}}, for signing up. Learn more here. For reprint requests, please see our Content Usage Policy. An important question raised by our results is the functional status of the p53 . It's thought that early exposure to UV light, in childhood and youth, contributes to the development of BCC and cSCC. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. National Cancer Institute. Treatment options for squamous cell skin cancer depend on the risk of the cancer coming back, which is based on factors like the size and location of the tumor and how the cancer cells look under a microscope, as well as if a person has a weakened immune system. Mayo Clinic does not endorse companies or products. Its the second most common type of skin cancer. Accessed at https://www.uptodate.com/contents/systemic-treatment-of-advanced-cutaneous-squamous-and-basal-cell-carcinomas on June 4, 2019. Avoiding the sun and using sunscreen may help protect against this skin cancer.This UV radiation also comes from commercial tanning lamps and tanning beds. Arsenic is known to perturb epidermal homeostasis and induce abnormal keratinocyte proliferation, leading to skin carcinogenesis. Bhanusivakumar RS, et al. They develop as the result of excess UV damage on sun-exposed surfaces of the body, including the face, neck, dorsal hands, and forearms, upper chest, back, and scalp [ 7, 9, 11, 12 ]. This retrospective study was carried out on 60 patients, including 40 cases with atypical squamous proliferation (10 cases with AK, 10 cases with BD and 20 cases with cSCC) and 20 normal controls. Our team is made up of doctors andoncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing. Though cSCC occurs less often, it may have more serious outcomes, including death. However, the Food and Drug Administration has not approved these methods for treating cSCC: Once cSCC has been treated, its critical to attend all follow-up visits with your doctor. Stage 1 Cancer has spread deep into the skin but has not spread to nearby lymph nodes or healthy tissues. Click here for an email preview. But BCC may also appear as: BCC occurs when one of the basal cells of the epidermis develops a mutation, or change, in its DNA. Cutaneous squamous cell carcinoma accounts for just one of every five cases but it is the more dangerous of the two. Squamous cell carcinoma is a malignant tumor arising from epidermal or appendageal keratinocytes or from the squamous mucosal epithelium.
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